The Government of Tamil Nadu has sanctioned the Third Veterinary College at Tirunelveli vide G.O. Ms. No. 93, Animal Husbandry, Dairying and Fisheries (AH-6) Department dated 24/08/2011. Tamil Nadu Veterinary and Animal Sciences University has started establishing the Veterinary College and Research Institute with full facilities for Veterinary Education, Research and Extension activities at Ramayanpatti in Tirunelveli, with a total area of 139.21 acres of land with an initial budget of Rs.12.59 crores to cater to the needs of the southern drought prone district farmers, who mainly depend on dairy, sheep and goat rearing for their daily livelihood.

The college was formally inaugurated by the Hon'ble Chief Minister of Tamil Nadu Selvi. J.Jayalalithaa on 09/10/2012 through video-conferencing from Chennai. The annual intake of the college is 40 students for the undergraduate degree programme of B.V.Sc. & A.H.

The Minister for Animal Husbandry, Tamil Nadu Thiru.T.K.M.Chinnayya visited the campus and reviewed the ongoing activities on 15/12/2012 along with the Commissioner of Animal Husbandry, Govt. of Tamil Nadu.	The team of experts from the VCI, New Delhi inspected the college for offering B.V.Sc. & A.H. course from 25/06/2012 to 27/06/2012 and the council approved the new college vide its Lr. F.No.17-25 (2011)/VCI/2192, dated 17/09/2012.

At present the college is functioning at three campuses as listed below:
Sripuram campus in the Tirunelveli city is functioning with the Office of the Dean, Library and departments viz., Veterinary Anatomy, Veterinary Physiology & Biochemistry, Animal Nutrition and Teaching Veterinary Clinical Complex.	Abhisekapatti campus, about 5 km from the Tirunelveli city on Tenkasi road is having two departments viz., Animal Genetics & Breeding and Livestock Production & Management and separate hostel facilities for boys and girls are also located in this campus.

Ramayanpatti campus, is about 5 km from the Tirunelveli city in Sankarankoil road and has the Instructional Livestock Farm Complex.