VACCINE RESEARCH CENTRE - VIRAL VACCINE

Vaccine Research Centre – Viral Vaccines was started on 10th October 1983 for conducting research on Vaccines and diagnostics development for important and emerging viral diseases affecting livestock and poultry. VRCVV is functioning as Plan scheme of Government of Tamil Nadu and is one of the constituent units of the Centre for Animal Health Studies, TANUVAS, Madhavaram Milk Colony Campus, Chennai –6000 51.

Objectives

  • Development of cost effective vaccines to cater the needs of farmers and livestock breeders
  • To improve the quality of existing vaccines
  • Development of field level diagnostic kits for rapid identification of causative agent
  • Development of conventional vaccines for the control of emerging poultry diseases
  • Establishment of Centre of Excellence in Vaccinology

Laboratory Facilities

  • The Cell Culture Laboratory is being utilized for the propagation of viruses and for development of vaccines for important poultry and livestock diseases.
  • The Serology Laboratory facilitates for the sero monitoring and sero diagnosis of important poultry and livestock diseases.
  • The Molecular Virology Laboratory facilitates for the molecular characterization of vaccine and field viruses and also for the molecular epidemiological studies of the viruses.
  • Identification facility for bluetongue virus vector, Culicoides.

Research Schemes Completed

Externally funded schemes

  • National
    • ICAR funded scheme "Antigenic, pathogenic and molecular characterization of field isolates of infectious bursal disease virus."
    • Board of Research on Nuclear Sciences, Government of India funded scheme "Molecular characterization of polypeptides of Rinderpest and PPR viruses."
    • National project on Rinderpest Eradication funded scheme "Development of a Homologous vaccine for Peste des petits ruminants."
    • ICAR funded scheme "Development of a Homologous vaccine for Contagious Ecthyma."
    • NADP funded scheme "Novel Diagnostics and vaccine Delivery system for emerging and economically important bacterial and viral diseases affecting small ruminants."
      Component 4 (Sheep pox) "Development of multiplex PCR assay and flow through membrane assay."
    • DBT Network scheme "Development of User-friendly, Discriminatory Diagnostics and New Generation vaccine for classical swine fever as co-centre for the live attenuated CSF vaccine."
    • DBT Scheme "Development of Molecular and immunodiagnostic kits for Hepatopancreatic parvovirus (HPV) in shrimp."
    • DST scheme "Identification and assessment of the expression profiles of important Toll-like receptors (TLRs) in commercially important food and ornamental fishes."
    • NAIP scheme "Toll-like receptors in phylogenetically divergent fish species and their contribution in modulation the innate immunity as Co-centre
    • DBT funded Network scheme on "Development of User-friendly, Discriminatory Diagnostics and New Generation vaccine for classical swine fever as co-centre for the live attenuated CSF vaccine".
  • International
    • SEPPIC and Yasham Bioscience funded project "Large Scale Field Testing of Inactivated Multivalent Adjuvanted Vaccine for Bluetongue."
    • Indo UK BBSRC funded project "Monitoring and Intervention Strategies for Bluetongue virus Epidemics in Rural India"
  • Government of Tamil Nadu Schemes
    • Development of bluetongue vaccine for sheep
    • Scheme on Strengthening the Vaccine Research Centre – Viral Vaccines for Molecular Epidemiology
    • Development of Bluetongue diagnostic kit
    • Simultaneous antibody screening to three major Poultry diseases
    • Assessment of Physical and Microbiological score for evolving standards for Chick Quality
    • Studies on Chicken Anaemia virus
    • Development of cell culture based vaccine for sheep pox
    • Plan scheme "Development of inactivated swine fever virus vaccine."
  • Self-financing scheme
    • Production and supply of biologicals, diagnostic reagents and for diagnostic services
    • Shrimp Disease Diagnostic Laboratory (Transferred to Tamil Nadu Fisheries University)

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Ongoing Research Schemes

Externally funded schemes

  • National
    • ICAR funded "All India Net Work Programme on bluetongue" TANUVAS Centre
    • ICAR funded "Veterinary Type Culture network Project " TANUVAS Centre with tribal sub-plan programme
    • SERB, DST Funded, "Development of diagnostic tools and vaccine for Porcine circovirus 2, an emerging pathogen."
  • International
    • • SEPPIC and Yasham Biosciences funded project on "Large Scale Field Testing of Inactivated Multivalent Adjuvanted Vaccine for Bluetongue".

Training

  • International Training Programme on Bluetongue vector identification
    • The International Training Programme on Bluetongue Vector Identification was organized by Vaccine Research Centre – Viral Vaccines, Centre for Animal Health Studies at the University Headquarters at Madhavaram Milk Colony Campus, Chennai -600 051 during 1st to 5th July, 2013. The Programme was funded by Biotechnology and Biological Sciences Research Council (BBSRC), UK as part of the ongoing UK-India collaborative project 'Monitoring and Intervention strategies for bluetongue virus epidemics in rural India'

 

  • Training on Animal Tissue Culture to field Veterinary Assistant Surgeons, life science undergraduate students, postgraduate students and faculty members of Universities on need basis.
  • Training programmes on Virological techniques to field Veterinary Assistant Surgeons and Postgraduate Life Science Students on need basis.

Utilization of Lab Facilities for Project Work

  • Students of TANUVAS and Several Life Science Postgraduate students of various Universities are utilizing the facilities of this unit to complete their Project work.

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Vaccines Developed

Inactivated Infectious Bursal
Disease Virus Vaccine
Inactivated Hydropericardium
Syndrome Vaccine
Inactivated Ranikhet Disease
Virus Vaccine
Adjuvant for Ranikhet disease
virus live vaccine
Bluetongue multivalent
inactivated vaccine
adjuvanted with
Montanide ISA 206

 

  • Live attenuated vaccines for contagious ecthyma, sheep pox and PPR
  • Inactivated  Classical Swine Fever vaccine.

Diagnostic Kits Developed

Infectious bursal disease Agar gel immunodiffusion test kit
Ranikhet disease virus haemagglutination inhibition test kit
  • Bluetongue disease virus agar gel immunodiffusion test kit
  • Hydropericardium syndrome Agar gel Immunodiffusion test kit

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Patents Published

  • Inactivated multivalent bluetongue vaccine.

Technology Released

  • Inactivated multivalent bluetongue virus vaccine
  • Infectious bursal disease virus Agar gel Immunodiffusion test kit
  • Hydropericardium syndrome Agar gel Immunodiffusion test kit
  • Inactivated Infectious Bursal Disease Virus Vaccine
  • Inactivated Hydropericardium Syndrome Vaccine
  • Inactivated Ranikhet Disease Virus Vaccine
  • Adjuvant for Ranikhet disease virus live vaccine

Commercialization of the Technology

  • The technology of Bluetongue Multivalent Inactivated Adjuvanted Vaccine was transferred to the animal vaccine companies for the large scale production

 

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Faculty

Dr.Y. Krishnamohan Reddy, Professor and Head | drykmreddy@hotmail.com
Dr. A. Ramesh | Professor | Email:a.ramesh@tanuvas.org.in
Dr. K.G. Tirumurugaan | Associate Professor (Working at TRPVB) | Email:tirumurugaankg@tanuvas.org.in
Dr. K. Brindha| Assistant Professor | Email:brindhak@tanuvas.org.in
Dr.K. Anbu Kumar, Assistant Professor | anbukarup@tanuvas.org.in
Dr. G. Athira | Graduate Assistant (Working at PLAFFS) | Mobile: 9578382412 | Email:athi.gnair95@gmail.com

Contact

Professor and Head
Vaccine Research Centre-Viral Vaccines,
Centre for Animal Health Studies
Tamil Nadu Veterinary and Animal Sciences University
Madhavaram Milk Colony, Chennai – 600 051
Telephone : 0091(0)44 25551573 | Mobile: 00919962754861
FAX : 044-25551577 | E Mail: vrcvv@tanuvas.org.in